This study presents a successful development of a discriminative colibacillosis model through aerosol inoculation of adult broiler breeders. coli exhibited clinical signs and developed characteristic gross and histopathological lesions of colibacillosis, including splenic fibrinoid necrosis, folliculitis, polyserositis and impaction of parabronchi with fibrinoheterophilic exudate and necrotic debris, as well as positive in situ localisation of intralesional E. All animals were thoroughly necropsied, and bacteriological samples were collected as well as tissues for histopathology. Alternating euthanasia time points were predetermined in order to evaluate the progression of the disease.
Replication of aerosol inoculation was performed on distinct days. Hens (n = 120) were randomly allocated into six groups receiving either aerosolised E. To aid future studies on disease mechanisms and interventions, an aerogenous infection model was established in adult broiler breeders. Escherichia coli constitutes an immense challenge to the poultry industry due to its devastating effect on productivity, mortality, and carcass condemnations.
